Anticancer Activity of Ag(I) N-Heterocyclic Carbene Complexes Derived from 4,5-Dichloro-1H-Imidazole

نویسندگان

  • Doug A. Medvetz
  • Khadijah M. Hindi
  • Matthew J. Panzner
  • Andrew J. Ditto
  • Yang H. Yun
  • Wiley J. Youngs
چکیده

A class of Ag(I) N-heterocyclic carbene silver complexes, 1-3, derived from 4,5-dichloro-1H-imidazole has been evaluated for their anticancer activity against the human cancer cell lines OVCAR-3 (ovarian), MB157 (breast), and Hela (cervical). Silver complexes 1-3 are active against the ovarian and breast cancer cell lines. A preliminary in vivo study shows 1 to be active against ovarian cancer in mice. The results obtained in these studies warrant further investigation of these compounds in vivo.

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عنوان ژورنال:

دوره 2008  شماره 

صفحات  -

تاریخ انتشار 2008